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Biosystems Modeling, Evolution and Engineering Laboratory

Exploring Biological Systems to understand the Synergy between its Components, from Cells to Microniche

GRN Topology & Dynamics · Transcriptomic & Functional Heterogeneity · Metabolic Heterogeneity · Transcriptional State Dynamics · Mathematical Modeling · Noise propagation · Evolutionary Biology · Machine Learning

Events

Done

February 25 · 5:00 PM

PhD synopsis seminar of Upasana Ray

Deciphering the topology and dynamics of gene regulatory networks driving cancer progression and therapy response.

Done

February 12 - 14, 2026

Workshop on Computational Oncology: Cancer as a Dynamic Complex System

The workshop brings together academic researchers, clinicians, and students working in theoretical and experimental cancer biology and therapeutics.

Research Highlights

Protein Noise Research

Protein Expression Noise

Investigating how ribosome demand links transcriptional bursts to protein noise, influencing phenotypic heterogeneity.

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Evolutionary Adaptation

Evolution & Adaptation

Exploring the role of cryptic vs de-novo mutations in adaptation to novel stressful environments using yeast models.

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Cancer Progression

Cancer Heterogeneity

Genome-wide identification of gene expression noise changes during cancer progression and its role in drug resistance.

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Recent Publications

  • 2024
    Ribosome demand links transcriptional bursts to protein expression noise Pal S., Ray U., Dhar R† eLife (2024)
  • 2024
    Exaptation and de novo mutations transcend cryptic variations as drivers of adaptation in yeast Routh S., Lindsay R., Gudelj I., Dhar R† bioRxiv (2024)

Life at BIOMÉ Lab

Lab Group Photo
Our interdisciplinary team at IIT Kharagpur.
Lab in Action
Dr. Samprti Pal earning her doctorate.
Lab in Action
Dr. Sherya Routh earning her doctorate.
Lab in Action
Old lab group photo from 2024.