Biosystems Modeling, Evolution and Engineering Laboratory
Investigating Biological Systems to Understand the Synergy Between its Components, from Cells to Microniche
GRN Topology & Dynamics · Transcriptomic & Functional Heterogeneity · Metabolic Heterogeneity · Transcriptional State Dynamics · Mathematical Modeling · Noise propagation · Evolutionary Biology · Machine Learning
Research Highlights
Protein Expression Noise
Investigating how ribosome demand links transcriptional bursts to protein noise, influencing phenotypic heterogeneity.
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Evolution & Adaptation
Exploring the role of cryptic vs de-novo mutations in adaptation to novel stressful environments using yeast models.
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Cancer Heterogeneity
Genome-wide identification of gene expression noise changes during cancer progression and its role in drug resistance.
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Our interdisciplinary team at IIT Kharagpur.
Dr. Samprti Pal earning her doctorate.
Dr. Sherya Routh earning her doctorate.