February 25
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5:00 PM
PhD synopsis seminar of Upasana Ray
Deciphering the topology and dynamics of gene regulatory networks driving cancer progression and therapy response.
Biosystems Modeling, Evolution and Engineering Laboratory
Exploring Biological Systems to understand the Synergy between its Components, from Cells to Microniche
GRN Topology & Dynamics • Transcriptomic & Functional Heterogeneity • Metabolic Heterogeneity • Transcriptional State Dynamics • Mathematical Modeling • Noise propagation • Evolutionary Biology • Machine Learning
Events
Feb 12 – 14, 2026
Workshop on Computational Oncology: Cancer as a Dynamic Complex System
The workshop brings together academic researchers, clinicians, and students working in theoretical and experimental cancer biology and therapeutics.
Research Highlights
Investigating how ribosome demand links transcriptional bursts to protein noise, influencing phenotypic heterogeneity in cell populations. Learn more →
Exploring the role of cryptic vs de-novo mutations in adaptation to novel stressful environments using yeast models. Learn more →
Genome-wide identification of gene expression noise changes during cancer progression and its role in drug resistance. Learn more →
Recent Publications
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2025
Pan-cancer analysis reveals mtDNA copy number as a key determinant of mutational load and disease progression in cancer bioRxiv (2025)
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2025
Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression npj Systems Biology and Applications (2025)
Life at BIOMÉ Lab
Biome Lab at IIT Kharagpur encompasses everything from cutting edge research to vibrant lab culture. Our interdisciplinary team of biologists, engineers, and students collaborate on on experimental research work as well as, rigrous computational modeling of biosystems. We foster a supportive environment that encourages creativity and pushes for unique personalized contributions. From celebrating milestones together to engaging in lively scientific discussions, life at Biome Lab is as dynamic and enriching as the research we conduct.
More coming soon... !